Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease

Blogspam. Nature article: https://www.nature.com/articles/s43587-021-00138-z >Based on retrospective case–control pharmacoepidemiologic analyses of insurance claims data for 7.23 million individuals, we found that sildenafil usage was significantly associated with a 69% reduced risk of AD (hazard ratio 0.31, 95% confidence interval 0.25–0.39, P < 1.0 × 10^–8). Retrospective study, so no causation proved, of course. That will require an actual randomized clinical trial, which hasn't been done.

Cialis has been linked to mitigation of cognitive decline: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705107/ https://www.nature.com/articles/s41598-019-53136-y And Viagra has been identified as a potential tool against Alzhimers: https://www.nature.com/articles/s43587-021-00138-z https://content.iospress.com/articles/journal-of-alzheimers-... Ideally, we'd identify the key mechanisms at play and be able to develop lifestyle modifications that would support them, but it's pretty cool that these drugs have benefits beyond just better bedroom performance.

Here's a better article (from a better source): https://www.bbc.com/news/health-59546948 The actual study isn't linked, but I believe it's this one: https://www.nature.com/articles/s43587-021-00138-z