Skip to content
The methodOpen data
Back to the collection

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

Purna Mukherjee, Zachary M. Augur, Mingyi Li

Show all 13 authors

Collin Hill, Bennett Greenwood, Marek A. Domin, Gramoz Kondakci, Niven R. Narain, Michael A. Kiebish, Roderick T. Bronson, Gabriel Arismendi-Morillo, Christos Chinopoulos, Thomas N. Seyfried

2019 · Communications Biology

NeuroscienceBiology & medicine
Read the paper
HN score
1.5
Mentions
3
Readers
3
Months
3
What’s in a score?

From the abstract

AbstractGlioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective therapy for decades. Although glucose and glutamine are the major fuels that drive GBM growth and invasion, few studies have targeted these fuels for therapeutic management. The glutamine antagonist, 6-diazo-5-oxo-L-norleucine (DON), was administered together with a calorically restricted ketogenic diet (KD-R) to treat late-stage orthotopic growth in two syngeneic GBM mouse models: VM-M3 and CT-2A. DON targets glutaminolysis, while the KD-R reduces glucose and, simultaneously, elevates neuroprotective and non-fermentable ketone bodies. The diet/drug therapeutic strategy killed tumour cells while reversing disease symptoms, and improving overall mouse survival. The therapeutic strategy also reduces edema, hemorrhage, and inflammation. Moreover, the KD-R diet facilitated DON delivery to the brain and allowed a lower dosage to achieve therapeutic effect. The findings support the importance of glucose and glutamine in driving GBM growth and provide a therapeutic strategy for non-toxic metabolic management.

Metadata: Crossref. Abstracts retain their original authors’ rights.

In the conversation

Original HN comments, with labels from simple text rules. A label describes the whole comment and may miss context or irony. Read the discussion to make up your own mind. About the labels

3 selected excerpts · 3 total mentions

systemsignal
Strong recommendation · rule
Highly recommend looking into the work of Thomas Seyfried, the metabolic theory of cancer, press-pulse approach, glutamine targeting Press-Pulse approach described: https://www.youtube.com/watch?v=q7kOs6bS1Hg&t=7185s (~ keto+exercise+hyperbaric oxygen therapy+standard approaches which become more effective) https://nutritionandmetabolism.biomedcentral.com/articles/10... https://www.bc.edu/bc-web/bcnews/science-tech-and-health/bio... https://www.nature.com/articles/s42003-019-0455-x https://pmc.ncbi.nlm.nih.gov/articles/PMC8200410/ https://www.youtube.com/watch?v=6PJfOFTaYow
Original comment Ask HN: A friend has brain cancer: any bio hacks that worked?
mromanuk
Neutral mention · rule
BTW, saying that someone "is a bit of a quack" is an ad hominem fallacy. The article linked talks about the "keto" part of the protocol, it does not discuss the glutamine portion of the treatment. I'm not sure who is right, but I would love to see, someone debunking it with data. Protocol: https://www.nature.com/articles/s42003-019-0455-x
Original comment Scientist treated her own cancer with viruses she grew in the lab
mindviews
Neutral mention · rule
A couple of interesting publications on Glioblastoma treatment that might be pointing in the right direction for targeting glucose and glutamine starting with mouse models: https://www.nature.com/articles/s42003-019-0455-x and progressing to human case study: https://www.ncbi.nlm.nih.gov/pubmed/29651419
Original comment Starving cancer by cutting off its favorite foods

Keep following the thread.

More in Neuroscience

More from the same topics.