Skip to content
Back to the collection

Not just antibodies: B cells and T cells mediate immunity to COVID-19

Rebecca J. Cox, Karl A. Brokstad

2020 · Nature Reviews Immunology

Read the paper
HN score
0
Mentions
3
Readers
3
Months
3
What’s in a score?

In the conversation

Original HN comments, with labels from simple text rules. A label describes the whole comment and may miss context or irony. Read the discussion to make up your own mind. About the labels

3 selected excerpts · 3 total mentions

kenjackson
Neutral mention · rule
It's hard to get proportionality w/o spending a lot of time getting data. But the simplest Google search and you can find Nature articles talking about T-cell response with respect to Covid: https://www.nature.com/articles/s41586-020-2550-z https://www.nature.com/articles/s41467-021-24377-1 https://www.nature.com/articles/s41577-020-00436-4 If you aren't aware of these discussions it's not because of lies of omission, gas lighting, or a vast conspiracy theory. It's because you buried your own head and then said someone is holding your head down.
rolph
Neutral mention · rule
There seems to be nothing in the article, or in the references suggesting that the vaccine provides any greater advantage other than avoiding morbidity and possible mortality. There seems to be a running premise that SARS-2 infection provides short term immunity at best, based on titre of antibodies. There is no immediate way to confirm or deny such a hypothesis, other than compare SARS-1 survivors to non SARS-1 survivors that have been recently exposed to the SARS pathogen. This would provide two points of comparison spaced 17 years apart. I was infected with SARS-1 in 2003 and recently with SARS-2 during the SARS-2 infection [asymptomatic] i was tested for antibodies.…
Read the full comment
the results indicated "one of the highest scores observed in my region" . 32 weeks post infection i am still providing antibodies for use in local infusion centres, and fortuitously i am a universal dOnor blood type. clearly in my case SARS-1 infection and recovery has provided protection 17 years later. I have since had long term repeated proximity contact with sars-2 positive individuals numerous times, without testing positive for the virus, and continue to provide serum. bear in mind i maintain self isolation from people not testing positive, and in one case have provided a direct transfusion to a fellow professional in a non clinical setting, and they kicked the virus to pieces in the space of a week. [redacted] ------------------------------------------------------- https://doi.org/10.1038/s41577-020-00436-4 "Studies of patients who became infected with SARS-CoV in 2003 suggested that the infection induced durable T cell responses lasting for 6 years but no long-term memory B cells [9]. Importantly, these T cells were shown to cross-react with the SARS-CoV-2 virus 17 years later [10], but the extent to which they can provide protection is not known. Most importantly, the early global sharing of scientific data is vitally important to understand the complexities of the B cell and T cell responses in COVID-19 and to elucidate which immune responses provide protection from both the initial infection and reinfection."
stephanheijl
Neutral mention · rule
Important notes: No data is available on actual illness according to the article, which means that while there could be an immune response, that does not mean that symptoms were observed. This study also does not regard the impact of T-cells, which were determined to mediate the immune response to COVID [1]. The paper acknowledges this shortcoming. [1] https://www.nature.com/articles/s41577-020-00436-4

Keep following the thread.

More in Biology & medicine

More from the same topics.