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More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Sandra Lopez-Leon, Talia Wegman-Ostrosky, Carol Perelman

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Rosalinda Sepulveda, Paulina A. Rebolledo, Angelica Cuapio, Sonia Villapol

2021 · Scientific Reports

Biology & medicineScience & research
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From the abstract

Abstract COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. PRISMA guidelines were followed. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included (age 17–87 years). The included studies defined long-COVID as ranging from 14 to 110 days post-viral infection. It was estimated that 80% of the infected patients with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). Multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.

Metadata: Crossref. Abstracts retain their original authors’ rights.

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Original HN comments, with labels from simple text rules. A label describes the whole comment and may miss context or irony. Read the discussion to make up your own mind. About the labels

3 selected excerpts · 3 total mentions

iainctduncan
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For the non antivax-conspiracy-nonsense take on why this might be happening correlated with the worldwide spread of Covid, here's just a few on long term damage from Covid on heart, kidneys, lungs, and liver. Long covid: Damage to multiple organs presents in young, low risk patients: https://www.bmj.com/content/371/bmj.m4470 More than 50 long-term effects of COVID-19: a systematic review and meta-analysis https://www.nature.com/articles/s41598-021-95565-8 Many Show Long-Term Organ Damage After COVID - WebMD https://www.webmd.com/lung/news/20210401/many-show-long-term... ... a review of COVID-19's extensive effects on virtually all the organs. It causes inflammation,…
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endotheliitis, vasoconstriction, hypercoagulability, and edema. Lymphocytopenia, elevated D-dimer, elevated fibrin degradation products (FDPs), and disseminated intravascular coagulation (DIC) are observed. Deep vein thrombosis (DVT), venous thromboembolism, pulmonary embolism (PE), systemic and pulmonary arterial thrombosis and embolism, ischemic stroke, and myocardial infarction (MI) are reported. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470660/ It's not the flu. At all.
Original comment US life insurance company paid out 163% more for deaths of workers 18-64 in 2021
yourapostasy
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I wonder if there is sufficient correlation to investigate for causation from the total number of US infected of around 43M [1] and COVID-19 sequalae prevalence of around 80% [2], of which easily half comprise one or more of: fatigue (58%), headache (44%), attention disorder (27%), and dyspnea (24%). All of which are functionally adverse effects upon work. Let's be generous and say 90% of the 43M infected come out 100% healthy. That's still 4.3M. I tend to give Nature articles the benefit of the doubt. 90% of 4.3M is still 3,870,000 able-bodied people taken out of the US workforce. That's enough to affect the margins. [1] https://www.statista.com/statistics/1101932/coronavirus-covi... [2] https://www.nature.com/articles/s41598-021-95565-8
Original comment Where Did All the Workers Go? (Editorial Board)

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