MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

solving the root causes of my suffering and not just the symptoms. Meditation, somatic experiencing and mdma therapy[1] are the main methods I found the most effective, in no particular order. I’m not looking to argue about your choice of treatment. If you want to share your experience or hear mine, give me a way to contact you. Have a good night/day. [1]https://www.nature.com/articles/s41591-021-01336-3

about. > Are these effect sizes plausible? Nature Medicine also published two critical commentaries on the paper. The first one points out the issue we discussed above: that the blinding was almost certainly compromised in the study, since the control group got a completely inert placebo and the treatment group surely could tell whether they’d been given ecstasy. Expectations could have played a major role, and might explain at least some of the huge difference between groups (the commentary also makes the interesting point that researchers used to be required to collect data on which condition patients thought they were in, but since 2010 this is no longer the case. It might be time to bring back this rule). The second commentary asked for studies with more relevant control groups and longer follow-up periods to check the safety of the treatment. The MAPS researchers also responded, somewhat limply. > The journal also published an entirely uncritical commentary co-authored by Imperial College London’s David Nutt. Remember him? He was Fired4Truth as a drugs adviser by the UK Labour government in 2009 for criticising government policy on drug classification; he’s now a major psychedelics researcher who co-authored the psilocybin trial we encountered above. The commentary calls MDMA “remarkable” three separate times in about 1,000 words (it’s true the effect sizes in the study are remarkable, but what if they’re due to expectancy bias?). It also says it’s likely that MDMA “will be an approved medication within a few years”. > So there’s a final potential harm that stems from the breathless hyping and cheerleading of psychedelic treatments way beyond the evidence: it could mean that therapies—which come with their own rare but real dangers—are approved and rolled out to large numbers of patients when we need a lot more evidence that they really are beneficial in the long term.

data indicate that, compared with manualized therapy with inactive placebo, MDMA-assisted therapy is highly efficacious in individuals with severe PTSD, and treatment is safe and well-tolerated, even in those with comorbidities. We conclude that MDMA-assisted therapy represents a potential breakthrough treatment that merits expedited clinical evaluation." So no matter how much questionable research there may be - and I'm sure it is a lot - let's not throw out the baby with the bathwater. There is also good research, and these drugs have the potential to make a huge difference.

block the therapeutic use of these life-changing therapies. Here is another video for anyone wanting to know more about the topic: (Lecture by Prof. David Nutt: The New Psychedelic Revolution) https://youtu.be/1JjzVcfei60 I'm optimistic that the next few decades will bring about better approaches to these massively underserved (and largely exploited and discarded) people. References: https://www.nature.com/articles/s41591-021-01336-3 https://www.tandfonline.com/doi/full/10.1080/09540261.2021.1...

evidence for the utility of psychedelics. Here are just a a few publications, which may interest you: https://www.nature.com/articles/s41591-021-01336-3 https://www.nejm.org/doi/full/10.1056/NEJMoa2032994 https://journals.sagepub.com/doi/full/10.1177/02698811166755... https://link.springer.com/article/10.1007/s00213-017-4771-x https://www.cambridge.org/core/journals/psychological-medici...