Jiajia Chen, Jie Wu, Shaorui Hao
Meifang Yang, Xiaoqing Lu, Xiaoxiao Chen, Lanjuan Li
2017 · Scientific Reports
Abstract Patients who survive influenza A (H7N9) virus infection are at risk of physical and psychological complications of lung injury and multi-organ dysfunction. However, there were no prospectively individualized assessments of physiological, functional and quality-of-life measures after hospital discharge. The current study aims to assess the main determinants of functional disability of these patients during the follow-up. Fifty-six influenza A (H7N9) survivors were investigated during the 2-year after discharge from the hospital. Results show interstitial change and fibrosis on pulmonary imaging remained 6 months after hospital discharge. Both ventilation and diffusion dysfunction improved, but restrictive and obstructive patterns on ventilation function test persisted throughout the follow-up period. For patients with acute respiratory distress syndrome lung functions improved faster during the first six months. Role-physical and Role-emotional domains in the 36-Item Short-Form Health Survey were worse than those of a sex- and age-matched general population group. The quality of life of survivors with ARDS was lower than those with no ARDS. Our findings suggest that pulmonary function and imaging findings improved during the first 6 months especially for those with ARDS, however long-term lung disability and psychological impairment in H7N9 survivors persisted at 2 years after discharge from the hospital.
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Influenza doesn't seem to spread as much beyond the respiratory system as COVID does. Most damage is to lungs. Influenza damage to other organs is known but rare. [1][2] [1] https://www.nature.com/articles/s41598-017-17497-6 [2] https://pubmed.ncbi.nlm.nih.gov/22948576/
I would like to point out that long-term effects are a possible outcome in many types of flu, not just covid ex. [1][2]. Given the combination of relatively short timeframe for covid studies, the unknown complications of living in lockdowns, and the general "don't care" attitude toward these effects in previous flus, the whole "Long Covid" story at least seems rather overblown. [1] https://www.nature.com/articles/s41598-017-17497-6 [2] https://www.labmate-online.com/news/chromatography/1/breakin...
Depends on what you consider significant. Even influenza itself is traumatic enough that the risk of long-term effects is part of public health planning; flu vaccines aren't considered so critical because of the "lie in bed eating chicken soup all week" cases. (Although I don't fully endorse everything upthread, and I'd agree there's not much risk of hidden damage where patients we think are recovered will actually end up being disabled.) The first study I could find from a quick search: https://www.nature.com/articles/s41598-017-17497-6
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