Shawn F. Sorrells, Mercedes F. Paredes, Arantxa Cebrian-Silla
Kadellyn Sandoval, Dashi Qi, Kevin W. Kelley, David James, Simone Mayer, Julia Chang, Kurtis I. Auguste, Edward F. Chang, Antonio J. Gutierrez, Arnold R. Kriegstein, Gary W. Mathern, Michael C. Oldham, Eric J. Huang, Jose Manuel Garcia-Verdugo, Zhengang Yang, Arturo Alvarez-Buylla
2018 · Nature
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3 selected excerpts · 3 total mentions
FTA: "A growing body of research suggested they could, but then a Nature paper[1] last year raised doubts." [1] https://www.nature.com/articles/nature25975 "Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults"
And yet when Arturo Alvarez-Buylla and his team of researchers actually searched for physical evidence of young neurons in adult brains, they found... nothing: https://www.nature.com/articles/nature25975 The studies which came before may be based on nonprimate animal models in which adult neurogenesis does occur. But the best evidence we have to date suggests that adult humans do not grow new neurons.
The original study https://www.nature.com/articles/nature25975 that prompted the SSC article has an interesting discussion of this result in their supplement: "A study using 14C birthdating on sorted NeuN+ nuclei suggested that hundreds of new neurons are generated per day in the adult human hippocampus, with little decline with age. The results obtained from this method differ from the data presented here and other histology studies that show a sharp decline in markers of newly formed neurons during early postnatal development. Birthdating with 14C relies on the isolation of neuronal nuclei using NeuN antibodies, but subpopulations of oligodendrocytes and microglia can…
also express NeuN. 14C could also possibly become incorporated into DNA through methylation or DNA repair independent of cell division, processes that have been shown to occur at higher rates in the hippocampus. The proposed addition of new neurons to the adult caudate nucleus using this method is not supported by other work in the human or BrdU labeling in adult macaques. The 14C method is an innovative approach to perform birthdating in postmortem human samples, but it has not been validated in animal studies."
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