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Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

Chansavath Phetsouphanh, David R. Darley, Daniel B. Wilson

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Annett Howe, C. Mee Ling Munier, Sheila K. Patel, Jennifer A. Juno, Louise M. Burrell, Stephen J. Kent, Gregory J. Dore, Anthony D. Kelleher, Gail V. Matthews

2022 · Nature Immunology

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Original HN comments, with labels from simple text rules. A label describes the whole comment and may miss context or irony. Read the discussion to make up your own mind. About the labels

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bugglebeetle
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Uh, no. Try reading a scientific study by immunologists instead of listening to podcasts by some crank MD: https://www.nature.com/articles/s41590-021-01113-x https://www.cell.com/immunity/fulltext/S1074-7613(23)00125-5
Original comment What if we tolerated diseases?
AnthonBerg
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There are many, many scientists who are attempting to warn us that isn’t nothing. The literature is piling up. Paper: Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection – https://doi.org/10.1038/s41590-021-01113-x Paper: “Excess risk for acute myocardial infarction mortality during the COVID-19 pandemic” — https://doi.org/10.1002/jmv.28187 Paper: “p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)” — https://doi.org/10.3389/fphar.2022.871583 SARS-CoV-2 directly and indirectly interferes with p53 expression and balance. On p53:…
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“p53, cellular tumor antigen p53 (UniProt name); p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.” — https://en.wikipedia.org/wiki/P53 The literature goes on and on and on. People really are not okay after contracting this virus. I know plenty of people who simply are not recovering after COVID illness. Friends. Close family. Kids. We are being warned. And crucially: We can clean this crap out of the air. Nobody has to breathe in SARS-CoV-2. We absolutely must demand that something is done. There’s lots and lots that can be done.
Original comment U.S. workers have gotten less productive – no one is sure why
seydor
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No it has very different outcomes The risk of complications increases in every new infection https://www.reuters.com/business/healthcare-pharmaceuticals/... Elevated memory problems, stroke, seizure https://www.nature.com/articles/s41591-022-02001-z immunological dysfunction https://www.nature.com/articles/s41590-021-01113-x https://health.ucdavis.edu/news/headlines/international-stud...
Original comment The Case for Wearing Masks Forever
seydor
Neutral mention · rule
As others said the booster doesnt seem to be much different than previous vaccines, and overall they are all low efficacy against infection. https://www.ecdc.europa.eu/en/publications-data/interim-anal... https://www.science.org/doi/10.1126/science.abq1841 However, there is a worrying stream of research indicating that covid outcomes are worse than we generally think they are, even in mild infections. https://onlinelibrary.wiley.com/doi/10.1002/jmv.28187 https://www.nature.com/articles/s41590-021-01113-x https://publications.aap.org/pediatrics/article/150/5/e20220...? And every reinfection seems to make it worse, so this thing should not be allowed to become 'endemic' https://www.nature.com/articles/s41591-022-02051-3 So it seems like other, more effective measures to reduce infections are more likely to keep people healthy rather than trying to reduce the severity of symptoms (which is what vaccines do atm)
Original comment Harvard mandates the bivalent Omicron-specific Covid-19 booster

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