Temporal dynamics in viral shedding and transmissibility of COVID-19

Here's a study that looks at the efficacy of Ivermectin within 72 hours of a fever or a cough: https://pubmed.ncbi.nlm.nih.gov/33495752/ And here is a study which looks at viral load since days of symptom onset, showing that at the 72 hour mark there is still plenty of Covid-19 in the body: https://www.nature.com/articles/s41591-020-0869-5 I am not a medical expert, so there may be things to criticize about these studies. All I meant to point out is that people are looking into / have looked at the questions you raise. Doctors and nurses are pretty burnt out; I for one think that they'd be looking for prophylactic treatments.

Unfortunately I think the media has really mixed up the words "presymptomatic" and "asymptomatic". You're right there is little evidence that people who never develop symptoms can spread COVID. But it seems likely that COVID can be spread up to 48 hours before symptoms develop, which still presents roughly the same problem. Here is a paper looking at viral shedding over time in COVID patients: https://www.nature.com/articles/s41591-020-0869-5 I also anecdotally know a few different people who caught COVID from someone who felt fine at the time they interacted, so I'm quite confident it is possible, although I'm not sure I'd make a strong statement about the prevalence.

> You are playing Russian roulette that I do not wish to play. In majority of the cases COVID-19 is not lethal at all You accuse them of playing Russian roulette while you justify not taking the vaccine with "the majority of COVID cases aren't lethal"? > I think this is way too overblown. 1.5 million people have died. > I want to know how likely it is for asymptomatic people to spread the virus. I swear, I will keep checking the responses because I am curious how likely it is that people will catch it from me If you're trying to determine the risk of someone catching it from you (and assuming that you'd immediately self-isolate when you start experiencing symptoms) you should be looking at pre-symptomatic transmission rather than just asymptomatic transmission. Here's a study that finds that around 44% of infections happened in the presymptomatic stage: https://www.nature.com/articles/s41591-020-0869-5?fbclid=IwA...

I have been reading this recent paper which suggests that c19 spreads most in the days before symptoms: https://www.nature.com/articles/s41591-020-0869-5

According to a paper published yesterday[1], the pre-symptomatic period is about 2.3 days[2]. [1] https://www.nature.com/articles/s41591-020-0869-5 [2] "we inferred that infectiousness started from 2.3 days (95% CI, 0.8–3.0 days) before symptom onset and peaked at 0.7 days (95% CI, −0.2–2.0 days) before symptom onset "