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Respiratory virus shedding in exhaled breath and efficacy of face masks

Nancy H. L. Leung, Daniel K. W. Chu, Eunice Y. C. Shiu

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Kwok-Hung Chan, James J. McDevitt, Benien J. P. Hau, Hui-Ling Yen, Yuguo Li, Dennis K. M. Ip, J. S. Malik Peiris, Wing-Hong Seto, Gabriel M. Leung, Donald K. Milton, Benjamin J. Cowling

2020 · Nature Medicine

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Original HN comments, with labels from simple text rules. A label describes the whole comment and may miss context or irony. Read the discussion to make up your own mind. About the labels

8 selected excerpts · 8 total mentions

jnbiche
Criticism · rule
> You've massively overstated those results. It's pretty fucking obvious that if you have Covid-19, and are expelling infected droplets into the air, almost any kind of mask will help reduce those droplets. I mean, wait for the double-blinded mask study (n=200) if you want. You may end up waiting for quite a while. Meanwhile, overall transmission rates in Asian mask-wearing countries are lower than Western transmission rates, despite taking many of the same precautions other than masks. The point with masks, even rudimentary ones, is that they help prevent the wearer from transmitting respiratory disease. And there's a point during a pandemic when you drop the…
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Nature/Science level of evidence when you're talking about a relatively low-risk intervention like wearing a bandana. In the words of the author of one the studies you disdain: "In normal times we'd say that if it wasn't shown statistically significant or the effective in real-world studies, we don't recommend it," he said. "But in the middle of a pandemic, we're desperate. The thinking is that even if it cuts down transmission a little bit, it's worth trying." BTW, the author of the study I'm talking about here studied transmission of viral infections (influenza and coronaviruses) with an n of 111, not bacterial infections: https://www.nature.com/articles/s41591-020-0843-2 But there are multiple studies from the past decade that indicate that masks help prevent spread of respiratory viruses. Finally, you harshly criticize my comment for lack of evidence, and yet you pull this one out: "It's likely that in members of the public the main route is touching an infected surface and then touching your eyes, nose or mouth." We have no idea if that's true or not at this point. And here's another statement you pulled out of nowhere: "As soon as you drop any of those you're not just making the mask a bit less effective, you're probably increasing the risk over not wearing a mask at all." You seem to have started from a position of defending the CDC, and then from there gone on cherry pick evidence or pull statements out of thin air. There are people I know working at the CDC that I respect a great deal. But this PR campaign to lie to the American people to preserve mask stocks was a bad, bad idea. > We know that qualified registered healthcare professionals who know the consequences of not wearing PPE correctly still struggle to do it all correctly. No significant difference between fitted and non-fitted N-95 masks: https://www.ncbi.nlm.nih.gov/pubmed/21477136 And no, I wasn't even talking about wearing hospital-level PPE. I was talking about masks, and even mentioned bandanas, for crying out loud. But keep on spearing that red herring. And here yet again, obviously N95 masks can help prevent transmission of respiratory viruses, including SARS-CoV-19. We know this to be true. > This is not the CDC / WHO / etc lying, this is them talking about the science as they understand it. You linked to some random ICU nurse, who makes some great points but has nothing to do with the CDC or WHO. But I agree that frontline health workers should absolutely have precedence to N-95 masks and other PPE. > You're basing this on a small study carried out in a lab using research bacteria (not viruses) carried in a calibrated spray, that didn't include "people breathing through the mask". Finally, you have no idea what I'm basing this on. Actually, it's common sense here that if you're infected, even as an asymptomatic carrier, wearing a bandana can reduce spread of droplets.
kgarten
Neutral mention · rule
Wearing a mask is a medical intervention for you?? wearing a mask is not about protecting you, it's protecting other people. If you don't value other people's lives, don't wear one it won't help you personally. Ok ... so where is the evidence that they don't work? Current scientific consensus is on my side of the debate: https://www.nature.com/articles/s41591-020-0843-2 https://www.nature.com/articles/d41586-020-02801-8 If you know better, do the experiments and the analysis, get it peer-reviewed and we can talk again. If you are ok with the consequences that you might kill people, don't wear a mask. Fine with me. Just don't tell anybody afterwards that you didn't know and that it was just a guess. i feel this discussion as tedious as the discussion about vaccinations: https://twitter.com/nathanTbernard/status/142511666690879488... People are no mannequins ... people die.
nathannecro
Neutral mention · rule
Hey, I appreciate that you have an opinion on this matter, but your opinion is directly opposed with scientific evidence on the matter. It turns out that wearing a simple surgical face mask dramatically reduces the detection of coronavirus in a closed laboratory setting over a period of 30 minutes (1). It also turns out that social distancing alone works too (2). Both reduce the R0 (reproduction number) of a disease. Masks reduce the "contagiousness" because fewer infectious droplets make it out into the open. Social distancing and quarantine measures reduce the likelihood of infectious transmission between infected and healthy individuals. This is multiplicative. For the…
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sake of easy numbers, let's assume that wearing a mask captures 90% of infectious droplets and that every meter of distance results in 60% of the droplets in the air to fall to the ground. If a sick individual wearing a mask coughs out 100 starting droplets and is 2 meters away from a healthy individual, the healthy individual will be breathing in 2.5 infectious droplets (100 * 0.10 * 0.50^2). This is multiplicative. For what it's worth, in real-world studies, when the use of face masks and/or social distancing became enforced, the rate at which infectious transmission occurred saw a measurable drop. The introduction of mandates requiring face masks (with social distancing already in effect) saw a 2% decline in the daily growth rate of COVID (3). If you'd like to read more, there is a recent meta-paper that surveys 172 different studies and concludes that: "The findings of this systematic review of 172 studies (44 comparative studies; n=25 697 patients) on COVID-19, SARS, and MERS provide the best available evidence that current policies of at least 1 m physical distancing are associated with a large reduction in infection, and distances of 2 m might be more effective. These data also suggest that wearing face masks protects people (both health-care workers and the general public) against infection by these coronaviruses, and that eye protection could confer additional benefit. However, none of these interventions afforded complete protection from infection, and their optimum role might need risk assessment and several contextual considerations. No randomised trials were identified for these interventions in COVID-19, SARS, or MERS." (4) 1: https://www.nature.com/articles/s41591-020-0843-2 2: https://www.thelancet.com/journals/laninf/article/PIIS1473-3... 3: https://www.healthaffairs.org/doi/10.1377/hlthaff.2020.00818 4: https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
DiogenesKynikos
Neutral mention · rule
Everyone now knows that the wearing of surgical masks by the general public is beneficial. That wasn't clear in late February and early March, and the scientific community was uncertain. That's why a paper finding that surgical masks are effective was important enough to be published in Nature Medicine as late as 3 April (and has been cited hundreds of times since).[1] It might seem obvious that surgical masks help, but there are a few reasons that people thought they might not: 1. Surgical masks let lots of unfiltered air in. 2. People might feel a false sense of security with masks, which could make them harmful. 3. People might touch their faces more when wearing…
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masks. Research like the paper I mentioned above, as well as the realization that asymptomatic and presymptomatic people play a large role in spreading the virus convinced the scientific community that widespread wearing of surgical masks is helpful. But blaming institutions for not knowing the right answer early on seems very unfair to me. 1. https://www.nature.com/articles/s41591-020-0843-2
jtoomim
Neutral mention · rule
That study is n=4. They didn't have enough statistical power to make any conclusions of that sort. Incidentally, if you look at the SK study's actual data, it appears that the cloth and surgical masks reduced the concentration of the virus by about 0.5 to 1.0 log units -- that is, by 66% to 90%. However, those results results were not statistically significant, because n=4. Nancy Leung, from Benjamin Cowling's lab in Hong Kong, did a much better study, n=114. They found that surgical masks did confer significant protective benefits. https://www.nature.com/articles/s41591-020-0843-2.pdf
nathannecro
Neutral mention · rule
I'm not one to touch politics, but wearing a mask is absolutely not a political statement. It's a sentiment that has been politicized, but the scientific argument for wearing a mask is very strong. See the study published in Nature (1), or recommendations from reputable medical institutions like the Cleveland Clinic (2) and the Mayo Clinic (3) for better explanations than I could give. I own several businesses in the hospitality and service sector and every single one of my employees are required to wear a mask for the protection of themselves and our guests. It's absolutely ridiculous that something as easy as wearing a mask is suddenly, "The Worst Thing in the World"…
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and/or, "The Most Uncomfortable Thing I've Ever Done". I have awful seasonal allergies and asthma and when I'm at the office or out and about in public, I will wear my surgical mask the entire time. The only time my mask is off is when I'm in my car or at home. I just can't get past the entitlement that some people have when they can't be bothered with sacrificing a tiny little bit of personal comfort to help slow the spread of a pandemic. 1: https://www.nature.com/articles/s41591-020-0843-2 2: https://health.clevelandclinic.org/heres-how-wearing-a-cloth... 3: https://www.mayoclinic.org/diseases-conditions/coronavirus/i... /rantover I apologize, but I'm just shocked. I expect better from my fellow HNers. Also, It's not entirely clear to me if you don't believe in wearing masks or if you're just making the comment that a mask is a political object (and by extension, websites should not display politically charged images). Either way, your comments in this thread have really thrown me for a loop.

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